Treatment of stiff person syndrome with rituximab
نویسندگان
چکیده
منابع مشابه
Treatment of stiff person syndrome with rituximab.
This case report is about the novel use of the anti-CD20 antibody, rituximab, in the treatment of a 41 year old woman with stiff person syndrome. She was admitted to hospital as an emergency with prolonged and painful extensor spasms affecting the neck and back, arms, and legs. The disease had progressed despite a favourable initial response to conventional treatment with intravenous immunoglob...
متن کاملChildhood Stiff-Person Syndrome Improved with Rituximab
INTRODUCTION Stiff-person syndrome (SPS) is manifested by fluctuating rigidity of axial musculature with painful episodic spasms due to simultaneous co-contraction of agonist and antagonist muscles. We present a case report and video illustrating response to treatment with rituximab. MATERIALS AND METHODS Case description and video are provided. A literature search for other reports of treatm...
متن کاملEvaluation of Treatment Outcomes in Patients with Stiff Person Syndrome with Rituximab vs. Standard of Care
Stiff Person Syndrome (SPS) is a rare neurological disorder that primarily affects the ability to relax musculature. This results in affected muscle groups remaining in constant contracture, leading to painful spasms that have significant morbidity and impact the patient's quality of life. Disease prevalence is one to two persons in a million, and as a result, very few randomized controlled stu...
متن کاملSuccessful treatment with rituximab in a patient with stiff-person syndrome complicated by dysthyroid ophthalmopathy.
We report a patient with stiff-person syndrome and insulin-dependent diabetes mellitus with anti-glutamic acid decarboxylase (GAD) antibody, who suddenly complained of diplopia due to dysthyroid ophthalmopathy. Therapeutic efficacy of plasmapheresis and high-dose intravenous immunoglobulin was transient. After starting administration of rituximab, the patient showed obvious improvement of muscl...
متن کاملTreatment of stiff-person syndrome with chronic plasmapheresis.
Stiff-person syndrome (SPS) is a disabling central nervous system disorder characterized by muscle stiffness, rigidity, and superimposed painful spasms affecting axial and proximal limb muscles. Electromyography shows continuous motor unit activity in axial muscles. There is strong evidence of an autoimmune pathogenesis for SPS. High levels of antibodies against the 65-kD isoform of glutamic ac...
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ژورنال
عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry
سال: 2005
ISSN: 0022-3050
DOI: 10.1136/jnnp.2004.051144